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Article

[Iron metabolism and iron-refractory iron deficiency anemia].

[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Jan 2020

Suzuki Takahiro

Abstract excerpt

Hepcidin is a key molecule that regulates iron metabolism in the body. Iron refractory iron deficiency anemia (IRIDA) is a genetic disorder caused by a defect in the TMPRSS6 gene encoding matriptase-2, a transmembrane serine protease that physiologically inhibits hepcidin production. In patients with IRIDA, the iron uptake in the intestine is remarkably reduced, and iron deficiency anemia (IDA) develops. However,...

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PMID: 32507812
DOI: 10.11406/rinketsu.61.475

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