Article
Transcriptomic Heterogeneity of Gleason Grade Group 5 Prostate Cancer.
European urology - 1 Sept 2020
Kishan Amar U, Romero Tahmineh, Alshalalfa Mohammed, Liu Yang, Tran Phuoc T, Nickols Nicholas G, Ye Huihui, Sajed Dipti, Rettig Matthew B, Reiter Robert E, Garraway Isla P, Spratt Daniel E, Freedland Steven J, Zhao Xin, Li Ziwen, Deek Matthew, Livingstone Julie, Mahal Brandon A, Nguyen Paul L, Feng Felix Y, Den Robert B, Schaeffer Edward M, Lotan Tamara L, Karnes R Jeffrey, Klein Eric A, Ross Ashley E, Grogan Tristan, Davicioni Elai, Elashoff David, Boutros Paul C, Weidhaas Joanne B
Abstract excerpt
Gleason grade group (GG) 5 prostate cancer has been associated with an aggressive natural history, and retrospective data support a role for treatment intensification. However, clinical outcomes remain heterogeneous in this cohort, and intensified treatments carry an increased risk of adverse events. We sought to explore the transcriptomic heterogeneity of GG 5 tumors by querying transcriptomic data from the...
Topics
- Aged
- Cohort Studies
- Genetic Variation
- Humans
- Male
- Middle Aged
- Neoplasm Grading
- Prostatic Neoplasms