Article
Homology Modeling and Virtual Screening of Proteins Related to PXE and PXE-like Diseases: Insights for Overlapping Metabolites.
Current pharmaceutical biotechnology - 1 Jan 2020
Naima Jannatul, Abir Ruhshan A, Hosen Mohammad J
Abstract excerpt
BACKGROUND: The molecular etiology of Pseudoxanthoma Elasticum (PXE), an autosomal recessive connective tissue disorder, has become increasingly complex as not only mutations in the ABCC6, but also in ENPP1 and GGCX, can cause resembling phenotypes. METHODS: To get insights on the common pathway, the overlapping metabolites for these three proteins were predicted through 3D homology modeling and virtual...
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