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Article

Heterogeneous Response to First-Generation Tyrosine Kinase Inhibitors in Non-Small-Cell Lung Cancers with Different EGFR Exon 19 Mutations.

Targeted oncology - 1 Jun 2020

Xu Haiyan, Li Weihua, Yang Guangjian, Li Junling, Yang Lu, Xu Fei, Yang Yaning, Ying Jianming, Wang Yan

Abstract excerpt

BACKGROUND: Epidermal growth factor receptor (EGFR) exon 19 deletions (19dels) appear in a large number of variants, which has not been distinguished in previously published trials despite differences in deletion and insertion locations. OBJECTIVE: The aim of this study was to investigate the therapeutic response of patients with different EGFR exon 19dels to first-generation tyrosine kinase inhibitors (TKIs) and...

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PMID: 32418166
DOI: 10.1007/s11523-020-00722-0

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