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Novel Drugs Targeting the SARS-CoV-2/COVID-19 Machinery

17 May 2020

Abstract excerpt

Like other human pathogenic viruses, coronavirus SARS-CoV-2 employs sophisticated macromolecular machines for viral host cell entry, genome replication and protein processing. Such machinery encompasses SARS-CoV-2 envelope spike (S) glycoprotein required for host cell entry by binding to the ACE2 receptor, viral RNA-dependent RNA polymerase (RdRp) and 3-chymotrypsin-like main protease (3Clpro/Mpro). Under the...

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PMID: 32416679
DOI: 10.2174/1568026620999200517043137

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