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Life-threatening pneumonitis after first-line treatment with osimertinib for primary T790M mutated non-small cell lung cancer.

Thoracic cancer - 1 Jul 2020

Häntschel Maik, Niebling Johannes, Häring Almut, Häring Max-Felix, Groß Thorben, Horger Marius, Riessen Reimer, Haap Michael, Lewis Richard A, Böckeler Michael, Hetzel Jürgen

Abstract excerpt

Epithelial growth factor receptor (EGFR) directed tyrosine kinase inhibitor (TKI) treatment is the standard approach in patients with advanced, EGFR-mutated non-small cell lung cancer (NSCLC). Although benefit/risk ratio is favorable for these TKI and side effects are manageable in the vast majority of patients, severe and even life-threatening side effects have been reported. TKI-induced interstitial lung...

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PMID: 32374485
DOI: 10.1111/1759-7714.13476
PMCID: PMC7327687

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