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Screening of OXA-244 producers, a difficult-to-detect and emerging OXA-48 variant?

31 Mar 2020

Abstract excerpt

BACKGROUND: OXA-244, a single amino acid variant of OXA-48, demonstrates weaker hydrolytic activity towards carbapenems and temocillin compared with OXA-48. Of note, these antimicrobials are present in high concentrations in several carbapenemase-producing Enterobacterales (CPE) screening media. As a result, some screening media fail to grow OXA-244-producing isolates, while the prevalence of OXA-244 producers is...

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PMID: 32363407
DOI: 10.1093/jac/dkaa155

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