Interregional spread in Spain of linezolid-resistant Enterococcus spp. isolates carrying the optrA and poxtA genes.

doi:10.1016/j.ijantimicag.2020.105977

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Article

Interregional spread in Spain of linezolid-resistant Enterococcus spp. isolates carrying the optrA and poxtA genes.

International journal of antimicrobial agents - 1 Jun 2020

Moure Zaira, Lara Noelia, Marín Mercedes, Sola-Campoy Pedro J, Bautista Verónica, Gómez-Bertomeu Frederic, Gómez-Dominguez Cristina, Pérez-Vázquez María, Aracil Belén, Campos José, Cercenado Emilia, Oteo-Iglesias Jesús

Abstract excerpt

The emergence of linezolid-resistant Enterococcus spp. (LRE) due to transferable resistance determinants is a matter of concern. To understand the contribution of the plasmid-encoded optrA and poxtA genes to the emergence of LRE, clinical isolates from different Spanish hospitals submitted to the Spanish Reference Laboratory from 2015-2018 were analysed. Linezolid resistance mechanisms were screened in all...

Topics

Aged
Anti-Bacterial Agents
Drug Resistance, Bacterial
Enterococcus faecalis
Enterococcus faecium
Female
Gene Transfer, Horizontal
Genome, Bacterial
Gram-Positive Bacterial Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Linezolid

Male

Molecular Epidemiology

Multilocus Sequence Typing

Mutation

Plasmids

Spain

Whole Genome Sequencing

Source

Open in PubMed

Identifiers

PMID: 32330583
DOI: 10.1016/j.ijantimicag.2020.105977

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