Article
Genetic and metabolic links between the murine microbiome and memory.
Microbiome - 17 Apr 2020
Mao Jian-Hua, Kim Young-Mo, Zhou Yan-Xia, Hu Dehong, Zhong Chenhan, Chang Hang, Brislawn Colin J, Fansler Sarah, Langley Sasha, Wang Yunshan, Peisl B Y Loulou, Celniker Susan E, Threadgill David W, Wilmes Paul, Orr Galya, Metz Thomas O, Jansson Janet K, Snijders Antoine M
Abstract excerpt
BACKGROUND: Recent evidence has linked the gut microbiome to host behavior via the gut-brain axis [1-3]; however, the underlying mechanisms remain unexplored. Here, we determined the links between host genetics, the gut microbiome and memory using the genetically defined Collaborative Cross (CC) mouse cohort, complemented with microbiome and metabolomic analyses in conventional and germ-free (GF) mice. RESULTS: A...
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