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Article

Novel Mutations in the TMPRSS3 Gene may Contribute to Taiwanese Patients with Nonsyndromic Hearing Loss.

International journal of molecular sciences - 30 Mar 2020

Wong Swee-Hee, Yen Yung-Chang, Li Shuan-Yow, Yang Jiann-Jou

Abstract excerpt

A previous study indicated that mutations in the transmembrane protease serine 3 (TMPRSS3) gene, which encodes a transmembrane serine protease, cause nonsyndromic hearing loss (NSHL). This was the first description of a serine protease involved in hearing loss (HL). In Taiwan, however, data on the TMPRSS3 gene's association with NSHL is still insufficient. In this study, we described 10 mutations of TMPRSS3 genes...

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Identifiers

PMID: 32235586
DOI: 10.3390/ijms21072382
PMCID: PMC7177719

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