Computational and experimental performance of CRISPR homing gene drive strategies with multiplexed gRNAs.

doi:10.1126/sciadv.aaz0525

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Article

Computational and experimental performance of CRISPR homing gene drive strategies with multiplexed gRNAs.

Science advances - 1 Mar 2020

Champer Samuel E, Oh Suh Yeon, Liu Chen, Wen Zhaoxin, Clark Andrew G, Messer Philipp W, Champer Jackson

Abstract excerpt

The rapid evolution of resistance alleles poses a major obstacle for genetic manipulation of populations with CRISPR homing gene drives. One proposed solution is using multiple guide RNAs (gRNAs), allowing a drive to function even if some resistant target sites are present. Here, we develop a model of homing mechanisms parameterized by experimental studies. Our model incorporates several factors affecting drives...

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Identifiers

PMID: 32181354
DOI: 10.1126/sciadv.aaz0525
PMCID: PMC7056305

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.