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Article

Maturational delay and asymmetric information flow of brain connectivity in SHR model of ADHD revealed by topological analysis of metabolic networks.

Scientific reports - 21 Feb 2020

Ha Seunggyun, Lee Hyekyoung, Choi Yoori, Kang Hyejin, Jeon Se Jin, Ryu Jong Hoon, Kim Hee Jin, Cheong Jae Hoon, Lim Seonhee, Kim Bung-Nyun, Lee Dong Soo

Abstract excerpt

Attention-deficit hyperactivity disorder (ADHD) is a complex brain development disorder characterized by hyperactivity/impulsivity and inattention. A major hypothesis of ADHD is a lag of maturation, which is supported mainly by anatomical studies evaluating cortical thickness. Here, we analyzed changes of topological characteristics of whole-brain metabolic connectivity in twelve SHR rats selected as ADHD-model...

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Identifiers

PMID: 32081992
DOI: 10.1038/s41598-020-59921-4
PMCID: PMC7035354

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