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Article

Roles of MicroRNAs in Esophageal Squamous Cell Carcinoma Pathogenesis.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2020

Islam Farhadul, Gopalan Vinod, Lam Alfred K

Abstract excerpt

MicroRNAs (miRNAs) are 20-22 nucleotides long single-stranded noncoding RNAs. They regulate gene expression posttranscriptionally by base pairing with the complementary sequences in the 3'-untranslated region of their targeted mRNA. Aberrant expression of miRNAs leads to alterations in the expression of oncogenes and tumor suppressors, thereby affecting cellular growth, proliferation, apoptosis, motility, and...

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PMID: 32056182
DOI: 10.1007/978-1-0716-0377-2_18

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