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Full genome based sequence and structural characterization of an unusual group A rotavirus G12P[11] isolated from neonates in Pune, western India.

Vaccine - 28 Feb 2020

Ranshing Sujata S, Cherian Sarah S, Agarwal Megha S, Jagtap Anuradha S, Patil Chinmayee M, Gopalkrishna Varanasi

Abstract excerpt

Studies conducted at neonatal intensive care units in Pune, western India, suggested early exposure to rotaviruses and predominance of unusual human-bovine-like G12P[11] strains. The whole genome sequencing and phylogenetic analyses of a naturally attenuated, culture adapted neonatal strain, (NIV-1740121) revealed multiple-gene reassortment events, containing ROTAVAC® vaccine strain, 116E-like VP4, VP6, NSP3,...

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PMID: 32029320
DOI: 10.1016/j.vaccine.2020.01.081

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