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Predicting fetoplacental mosaicism during cfDNA-based NIPT

24 Jan 2020

Abstract excerpt

PURPOSE OF REVIEW: Cell-free DNA-based noninvasive prenatal testing (cfDNA-based NIPT) using maternal blood is highly sensitive for detecting fetal trisomies. However, false-positive and false-negative results can occur, which prevents NIPT from being a diagnostic test. Fetoplacental mosaicism is one of the main reasons for discordant test results. It is therefore important to understand this phenomenon to enable...

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Share to Fetal and Pediatric Neurological Disorders
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PMID: 31977337
DOI: 10.1097/gco.0000000000000610

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