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Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys

23 Jan 2020

Abstract excerpt

Mouse kidney parvovirus (MKPV) is a member of the provisional genus Chapparvovirus that causes renal disease in immune-compromised mice, with a disease course reminiscent of polyomavirus-associated nephropathy in immune-suppressed kidney transplant patients. Here we map four major MKPV transcripts, created by alternative splicing, to a common initiator region, and use mass spectrometry to identify "p10" and "p15"...

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PMID: 31971979
DOI: 10.1371/journal.ppat.1008262

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