Insight Into Long Noncoding RNA–miRNA–mRNA Axes in Myocardial Ischemia-Reperfusion Injury: The Implications for Mechanism and Therapy

Abstract excerpt

Emerging evidence has demonstrated that regulatory noncoding RNAs (ncRNAs), such as long noncoding RNAs (lncRNAs) and miRNAs, play crucial roles in the initiation and progress of myocardial ischemia-reperfusion injury (MIRI), which is associated with autophagy, apoptosis and necrosis of cardiomyocytes, as well as oxidative stress, inflammation and mitochondrial dysfunction. LncRNAs serve as a precursor or host of...

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