AMG 510 First to Inhibit “Undruggable” KRAS

Abstract excerpt

Abstract Amgen's novel small-molecule inhibitor AMG 510 has become the first drug to successfully target a KRAS mutation in patients, according to findings presented at the 2019 American Society of Clinical Oncology Annual Meeting. In a phase I trial, AMG 510 elicited partial responses in half of evaluable patients with KRASG12C-mutant non–small cell lung cancer, and led to stable disease in most evaluable...

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