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Article

Ceftazidime-Avibactam in Combination With Fosfomycin: A Novel Therapeutic Strategy Against Multidrug-Resistant Pseudomonas aeruginosa.

The Journal of infectious diseases - 19 Jul 2019

Papp-Wallace Krisztina M, Zeiser Elise T, Becka Scott A, Park Steven, Wilson Brigid M, Winkler Marisa L, D'Souza Roshan, Singh Indresh, Sutton Granger, Fouts Derrick E, Chen Liang, Kreiswirth Barry N, Ellis-Grosse Evelyn J, Drusano George L, Perlin David S, Bonomo Robert A

Abstract excerpt

Previously, by targeting penicillin-binding protein 3, Pseudomonas-derived cephalosporinase (PDC), and MurA with ceftazidime-avibactam-fosfomycin, antimicrobial susceptibility was restored among multidrug-resistant (MDR) Pseudomonas aeruginosa. Herein, ceftazidime-avibactam-fosfomycin combination therapy against MDR P. aeruginosa clinical isolate CL232 was further evaluated. Checkerboard susceptibility analysis...

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Identifiers

PMID: 31099835
DOI: 10.1093/infdis/jiz149
PMCID: PMC6639593

Genes

PDC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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