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Refining the Phenotype of Recurrent Rearrangements of Chromosome 16

4 Mar 2019

Abstract excerpt

Chromosome 16 is one of the most gene-rich chromosomes of our genome, and 10% of its sequence consists of segmental duplications, which give instability and predisposition to rearrangement by the recurrent mechanism of non-allelic homologous recombination. Microarray technologies have allowed for the analysis of copy number variations (CNVs) that can contribute to the risk of developing complex diseases. By array...

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PMID: 30836598
DOI: 10.3390/ijms20051095

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