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The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species

19 Feb 2019

Abstract excerpt

Ageing constitutes the most important risk factor for all major chronic ailments, including malignant, cardiovascular and neurodegenerative diseases. However, behavioural and pharmacological interventions with feasible potential to promote health upon ageing remain rare. Here we report the identification of the flavonoid 4,4'-dimethoxychalcone (DMC) as a natural compound with anti-ageing properties. External DMC...

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PMID: 30783116
DOI: 10.1038/s41467-019-08555-w

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