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A Controlled Human Infection Model of Group A Streptococcus Pharyngitis: Which Strain and Why?

12 Feb 2019

Abstract excerpt

GAS ( Streptococcus pyogenes ) is a leading global cause of infection-related morbidity and mortality. A modern CHIM of GAS pharyngitis could help to accelerate vaccine development and drive pathogenesis research. Challenge strain selection is critical to the safety and success of any CHIM and especially so for an organism such as GAS, with its wide strain diversity and potential to cause severe life-threatening...

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PMID: 30760615
DOI: 10.1128/msphere.00647-18

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