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To B12 or not to B12: Five questions on the role of cobalamin in host-microbial interactions

3 Jan 2019

Abstract excerpt

How do mammals acquire cobalamin?Only a limited number of bacteria and archaea generate cobalamin de novo [1].Moreover, plants and fungi do not require cobalamin; therefore, humans obtain cobalamin through consumption of animal products.During digestion, cobalamin is absorbed in the ileum.Although some colonic bacteria produce cobalamin, humans are not able to uptake cobalamin produced at this location, and thus,...

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PMID: 30605490
DOI: 10.1371/journal.ppat.1007479

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