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Article

Efficacy of Ruxolitinib Therapy in a Patient With Severe Enterocolitis Associated With a STAT3 Gain-of-Function Mutation

15 Dec 2018

Abstract excerpt

Severe enterocolitis raises diagnostic and therapeutic challenges. Empirical treatment by steroids and immunosuppressive drugs is commonly used but, to date, little attempt has been made to specifically target the mechanism underlying inflammation. Possible causes of severe enterocolitis include refractory celiac disease,1 autoimmune enteropathy,2 and common variable immunodeficiency,3 the 2 latter being...

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PMID: 30557559
DOI: 10.1053/j.gastro.2018.11.065

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