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Origins of the 1918 Pandemic: Revisiting the Swine “Mixing Vessel” Hypothesis

19 Jul 2018

Abstract excerpt

How influenza A viruses host-jump from animal reservoir species to humans, which can initiate global pandemics, is a central question in pathogen evolution. The zoonotic and spatial origins of the influenza virus associated with the "Spanish flu" pandemic of 1918 have been debated for decades. Outbreaks of respiratory disease in US swine occurred concurrently with disease in humans, raising the possibility that...

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PMID: 30508193
DOI: 10.1093/aje/kwy150

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