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Article

Minimal microsatellite shift in microsatellite instability high endometrial cancer: a significant pitfall in diagnostic interpretation.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 May 2019

Wu Xinyu, Snir Olivia, Rottmann Douglas, Wong Serena, Buza Natalia, Hui Pei

Abstract excerpt

Mismatch-repair deficiency testing plays a critical role in the identification of proband in Lynch Syndrome families and triaging patients with high stage or recurrent solid malignancies for check point inhibitor (Pembrolizumab) immunotherapy. We compared microsatellite shift patterns of microsatellite instability PCR analysis at 5 NCI recommended loci between microsatellite instability high endometrial carcinoma...

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Identifiers

PMID: 30443012
DOI: 10.1038/s41379-018-0179-3

Genes

MSH6
PMS2
MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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