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Article

Acute Toxoplasma Gondii Infection in Cats Induced Tissue-Specific Transcriptional Response Dominated by Immune Signatures

19 Oct 2018

Abstract excerpt

We used RNA-sequencing to detect transcriptional changes in six tissues of cats 7 days after T. gondii infection. 737 genes were differentially expressed (DEGs), of which 410 were up-regulated and 327 were down-regulated. The liver exhibited 151 DEGs, lung (149 DEGs), small intestine (130 DEGs), heart (123 DEGs), brain (104 DEGs), and spleen (80 DEGs) – suggesting tissue-specific transcriptional patterns. Gene...

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PMID: 30405608
DOI: 10.3389/fimmu.2018.02403

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