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Article

MiRNA-335-5p negatively regulates granulosa cell proliferation via SGK3 in PCOS

4 Sept 2018

Abstract excerpt

Polycystic ovary syndrome (PCOS) is a major cause of infertility in women of reproductive age. However, its exact etiology remains unknown. In this study, we sequenced miRNAs in human follicular fluid and identified 16 downregulated and 3 upregulated miRNAs in PCOS group compared with non-PCOS group. Among the differential expressed miRNAs, miR-335-5p was verified lower abundance in PCOS than non-PCOS group using...

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PMID: 30328340
DOI: 10.1530/rep-18-0229

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