Deep brain stimulation is effective in pediatric patients with GNAO1 associated severe hyperkinesia.

doi:10.1016/j.jns.2018.05.018

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Article

Deep brain stimulation is effective in pediatric patients with GNAO1 associated severe hyperkinesia.

Journal of the neurological sciences - 15 Aug 2018

Koy Anne, Cirak Sebahattin, Gonzalez Victoria, Becker Kerstin, Roujeau Thomas, Milesi Christophe, Baleine Julien, Cambonie Gilles, Boularan Alain, Greco Frederic, Perrigault Pierre-Francois, Cances Claude, Dorison Nathalie, Doummar Diane, Roubertie Agathe, Beroud Christophe, Körber Friederike, Stüve Burkhard, Waltz Stephan, Mignot Cyril, Nava Caroline, Maarouf Mohammad, Coubes Philippe, Cif Laura

Abstract excerpt

BACKGROUND: Exacerbation of hyperkinesia is a life-threatening complication of dyskinetic movement disorders, which can lead to multi-organ failure and even to death. GNAO1 has been recently identified to be involved in the pathogenesis of early infantile epileptic encephalopathy and movement disorders. Patients with GNAO1 mutations can present with a severe, progressive hyperkinetic movement disorder with...

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Identifiers

PMID: 30103967
DOI: 10.1016/j.jns.2018.05.018

Genes

GNAO1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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