Article
Antigenic mimicry of ubiquitin by the gut bacteriumBacteroides fragilis: a potential link with autoimmune disease
7 Aug 2018
Abstract excerpt
Ubiquitin is highly conserved across eukaryotes and is essential for normal eukaryotic cell function. The bacterium Bacteroides fragilis is a member of the normal human gut microbiota, and the only bacterium known to encode a homologue of eukaryotic ubiquitin. The B. fragilis gene sequence indicates a past horizontal gene transfer event from a eukaryotic source. It encodes a protein (BfUbb) with 63% identity to...
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