Article
[What gnaws at the heart and gets on the nerves].
Der Internist - 1 Nov 2018
Kristen Arnt V
Abstract excerpt
Transthyretin is a transport protein for thyroxine and retinol-binding protein, which is mainly produced in the liver. Hereditary transthyretin-related amyloidosis (ATTR) is caused by one of more than 120 point mutations in the transthyretin gene and inherited as an autosomal dominant disorder. The mutations cause a reduction in the stability of the tetrameric structure and dissociation into dimers and monomers...
Topics
- Aged
- Amyloid
- Amyloid Neuropathies, Familial
- Benzoxazoles
- Cardiomyopathies
- Drug Approval
- Humans
- Middle Aged
- Mutation
- Polyneuropathies
- Prealbumin
- Quality of Life