Article
High-risk myeloma and minimal residual disease postautologous-HSCT predict worse outcomes.
Leukemia & lymphoma - 1 Feb 2019
Hu Bei, Thall Peter, Milton Denái R, Sasaki Koji, Bashir Qaiser, Shah Nina, Patel Krina, Popat Uday, Hosing Chitra, Nieto Yago, Lin Pei, Delgado Ruby, Jorgensen Jeffrey, Manasanch Elisabet, Weber Donna, Thomas Sheeba, Orlowski Robert Z, Champlin Richard, Qazilbash Muzaffar H
Abstract excerpt
The aim of our study was to determine the impact of high-risk disease (HRD) and MRD on outcomes in myeloma patients receiving bortezomib-based induction followed by autologous hematopoietic stem cell transplant (auto-HSCT). HRD included t(4:14), t(14;16), del 17p, del 1p and/or amplification 1q by cytogenetics/FISH; all others were standard-risk disease (SRD). A subset of 165 newly diagnosed myeloma patients in a...
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