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Article

Role of hepatoma-derived growth factor in promoting de novo lipogenesis and tumorigenesis in hepatocellular carcinoma.

Molecular oncology - 1 Sept 2018

Min Xuejie, Wen Jun, Zhao Li, Wang Kaiying, Li Qingli, Huang Gang, Liu Jianjun, Zhao Xiaoping

Abstract excerpt

Although identified as a growth factor, the mechanism by which hepatoma-derived growth factor (HDGF) promotes cancer development remains unclear. We found that nuclear but not cytoplasmic HDGF is closely associated with prognosis of hepatocellular carcinoma (HCC). RNA-sequencing analysis further demonstrated that the nuclear role of HDGF involved regulation of transcription of lipid metabolism genes. HDGF-induced...

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Identifiers

PMID: 30004626
DOI: 10.1002/1878-0261.12357
PMCID: PMC6120245

Genes

HDGF

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