Therapeutic potential of combined BRAF/MEK blockade in BRAF-wild type preclinical tumor models.

doi:10.1186/s13046-018-0820-5

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Article

Therapeutic potential of combined BRAF/MEK blockade in BRAF-wild type preclinical tumor models.

Journal of experimental & clinical cancer research : CR - 9 Jul 2018

Del Curatolo Anais, Conciatori Fabiana, Cesta Incani Ursula, Bazzichetto Chiara, Falcone Italia, Corbo Vincenzo, D'Agosto Sabrina, Eramo Adriana, Sette Giovanni, Sperduti Isabella, De Luca Teresa, Marabese Mirko, Shirasawa Senji, De Maria Ruggero, Scarpa Aldo, Broggini Massimo, Del Bufalo Donatella, Cognetti Francesco, Milella Michele, Ciuffreda Ludovica

Abstract excerpt

BACKGROUND: Mounting evidence suggests that RAF-mediated MEK activation plays a crucial role in paradox MAPK (re)activation, leading to resistance and therapeutic failure with agents hitting a single step along the MAPK cascade. METHODS: We examined the molecular and functional effects of single and combined BRAF (dabrafenib), pan-RAF (RAF265), MEK (trametinib) and EGFR/HER2 (lapatinib) inhibition, using Western...

Topics

Animals
Antineoplastic Agents
Cell Line, Tumor
Disease Models, Animal
Humans
Imidazoles
MAP Kinase Signaling System
Mice
Mitogen-Activated Protein Kinase Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Neoplastic Stem Cells

Oximes

Protein Kinase Inhibitors

Proto-Oncogene Proteins B-raf

Proto-Oncogene Proteins p21(ras)

Pyridones

Pyrimidinones

Xenograft Model Antitumor Assays

Source

Open in PubMed Open full text

Identifiers

PMID: 29986755
DOI: 10.1186/s13046-018-0820-5
PMCID: PMC6038340

Genes

BRAF
EGFR
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-29986755-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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