Article
Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics.
Scientific reports - 3 Jul 2018
Nagy-Szakal Dorottya, Barupal Dinesh K, Lee Bohyun, Che Xiaoyu, Williams Brent L, Kahn Ellie J R, Ukaigwe Joy E, Bateman Lucinda, Klimas Nancy G, Komaroff Anthony L, Levine Susan, Montoya Jose G, Peterson Daniel L, Levin Bruce, Hornig Mady, Fiehn Oliver, Lipkin W Ian
Abstract excerpt
The pathogenesis of ME/CFS, a disease characterized by fatigue, cognitive dysfunction, sleep disturbances, orthostatic intolerance, fever, irritable bowel syndrome (IBS), and lymphadenopathy, is poorly understood. We report biomarker discovery and topological analysis of plasma metabolomic, fecal bacterial metagenomic, and clinical data from 50 ME/CFS patients and 50 healthy controls. We confirm reports of...
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