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Article

Mechanisms of RsaL mediated tolerance to ciprofloxacin and carbenicillin in Pseudomonas aeruginosa.

Current genetics - 1 Feb 2019

Fan Zheng, Xu Chang, Pan Xiaolei, Dong Yuanyuan, Ren Huan, Jin Yongxin, Bai Fang, Cheng Zhihui, Jin Shouguang, Wu Weihui

Abstract excerpt

The Pseudomonas aeruginosa RsaL is a negative regulator of the quorum sensing signal synthesis gene lasI. The expression of RsaL is directly activated by the LasI cognate regulator LasR. Thus, RsaL and LasI-LasR (LasI/R) form a regulatory loop. Further studies revealed that RsaL is a global regulator which controls the expression of numerous genes through quorum sensing system dependent and independent pathways....

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PMID: 29951698
DOI: 10.1007/s00294-018-0863-3

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