AGTR2 absence or antagonism prevents cystic fibrosis pulmonary manifestations.

doi:10.1016/j.jcf.2018.05.013

Article

AGTR2 absence or antagonism prevents cystic fibrosis pulmonary manifestations.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Jan 2019

Darrah Rebecca J, Jacono Frank J, Joshi Neha, Mitchell Anna L, Sattar Abdus, Campanaro Cara K, Litman Paul, Frey Jennifer, Nethery David E, Barbato Eric S, Hodges Craig A, Corvol Harriet, Cutting Garry R, Knowles Michael R, Strug Lisa J, Drumm Mitchell L

Abstract excerpt

BACKGROUND: Pulmonary disease remains the primary cause of morbidity and mortality for individuals with cystic fibrosis (CF). Variants at a locus on the X-chromosome containing the type 2 angiotensin II receptor gene (AGTR2) were identified by a large GWAS as significantly associating with lung function in CF patients. We hypothesized that manipulating the angiotensin-signaling pathway may yield clinical benefit...

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