Article
The development of induced pluripotent stem cell-derived mesenchymal stem/stromal cells from normal human and RDEB epidermal keratinocytes.
Journal of dermatological science - 1 Sept 2018
Nakayama Chihiro, Fujita Yasuyuki, Matsumura Wakana, Ujiie Inkin, Takashima Shota, Shinkuma Satoru, Nomura Toshifumi, Abe Riichiro, Shimizu Hiroshi
Abstract excerpt
BACKGROUND: Epidermolysis bullosa (EB) is a group of hereditary disorders caused by mutations in the genes encoding structural molecules of the dermal-epidermal junction (DEJ). Cell-based therapies such as allogeneic mesenchymal stem/stromal cell (MSC) transplantation have recently been explored for severe EB types, such as recessive dystrophic EB (RDEB). However, hurdles exist in current MSC-based therapies,...
Topics
- Aged
- Animals
- Case-Control Studies
- Cell Lineage
- Cell Separation
- Cells, Cultured
- Collagen Type VII
- Disease Models, Animal
- Epidermolysis Bullosa Dystrophica
- Female