Article
Next-generation sequencing improves treatment efficacy and reduces hospitalization in children with drug-resistant epilepsy.
CNS neuroscience & therapeutics - 1 Jan 2019
Peng Jing, Pang Nan, Wang Ying, Wang Xiao-Le, Chen Jian, Xiong Juan, Peng Pan, Zhu Can-Hui, Kessi Miriam Barakael, He Fang, Yin Fei
Abstract excerpt
BACKGROUND: The purposes of this study were three-fold: (i) to determine the contribution of known genes to the causation of a broad-spectrum of pediatric drug-resistant epilepsy (DRE), (ii) to compare the diagnostic yield and cost among different next-generation sequencing (NGS) approaches, and especially (iii) to assess how NGS approaches can benefit patients by improving diagnosis and treatment efficiency....
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