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Feasibility of analysis of the SCN5A gene in paraffin embedded samples in sudden infant death cases at the Pretoria Medico-Legal Laboratory, South Africa.

Forensic science, medicine, and pathology - 1 Sept 2018

van Deventer Barbara Ströh, du Toit-Prinsloo Lorraine, van Niekerk Chantal

Abstract excerpt

To determine variations in the SCN5A gene linked to inherited cardiac arrhythmogenic disorders in sudden, unexplained infant death (SUID) cases examined at the Pretoria Medico-Legal Laboratory, South Africa. A retrospective study was conducted on SUID cases and controls, analyzing DNA extracted from archived formalin-fixed, paraffin-embedded (FFPE) myocardial tissue samples as well as blood samples. A total of 48...

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PMID: 29907895
DOI: 10.1007/s12024-018-9995-5

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