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Article

MiR-21 in extracellular vesicles contributes to the growth of fertilized eggs and embryo development in mice

8 Jun 2018

Abstract excerpt

Human preimplantation embryo development is susceptible to high rates of early embryo wastage. We determined the miR-21 expression of extracellular vesicles (EVs) in fertilized eggs and embryos of varying stages and their response to miR-21 microinjection. Sexually mature female and male mice were mated. Next, the expression and immunohistochemistry intensity of surface markers (CD9 and CD63) of EVs were detected...

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PMID: 29884767
DOI: 10.1042/bsr20180036

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