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Can inflammatory markers in induced sputum be used to detect phenotypes and endotypes of pediatric severe therapy-resistant asthma?

Pediatric pulmonology - 1 Sept 2018

Eller Miriam C N, Vergani Karina P, Saraiva-Romanholo Beatriz M, Antonangelo Leila, Leone Claudio, Rodrigues Joaquim C

Abstract excerpt

BACKGROUND: The phenotypes and endotypes of severe therapy-resistant asthma (STRA) have not been fully elucidated in children. The aim of the present study was to investigate inflammatory markers in the induced sputum of children with STRA and to compare them with those present in a group of children who achieved control. METHODS: A prospective cohort of children (6-18 years of age) diagnosed with severe asthma...

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PMID: 29870159
DOI: 10.1002/ppul.24075

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TNF

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