Article
Short hypervariable microhaplotypes: A novel set of very short high discriminating power loci without stutter artefacts.
Forensic science international. Genetics - 1 Jul 2018
van der Gaag Kristiaan J, de Leeuw Rick H, Laros Jeroen F J, den Dunnen Johan T, de Knijff Peter
Abstract excerpt
Since two decades, short tandem repeats (STRs) are the preferred markers for human identification, routinely analysed by fragment length analysis. Here we present a novel set of short hypervariable autosomal microhaplotypes (MH) that have four or more SNPs in a span of less than 70 nucleotides (nt). These MHs display a discriminating power approaching that of STRs and provide a powerful alternative for the...
Topics
- Alleles
- Artifacts
- DNA Fingerprinting
- Haplotypes
- High-Throughput Nucleotide Sequencing
- Humans
- Multiplex Polymerase Chain Reaction
- Polymorphism, Single Nucleotide
- Sequence Analysis, DNA