Article
Complex roads from genotype to phenotype in dilated cardiomyopathy: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology.
Cardiovascular research - 1 Aug 2018
Bondue Antoine, Arbustini Eloisa, Bianco Anna, Ciccarelli Michele, Dawson Dana, De Rosa Matteo, Hamdani Nazha, Hilfiker-Kleiner Denise, Meder Benjamin, Leite-Moreira Adelino F, Thum Thomas, Tocchetti Carlo G, Varricchi Gilda, Van der Velden Jolanda, Walsh Roddy, Heymans Stephane
Abstract excerpt
Dilated cardiomyopathy (DCM) frequently affects relatively young, economically, and socially active adults, and is an important cause of heart failure and transplantation. DCM is a complex disease and its pathological architecture encounters many genetic determinants interacting with environmental factors. The old perspective that every pathogenic gene mutation would lead to a diseased heart, is now being...
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