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Genetic contribution to mesenchymal stem cell dysfunction in systemic lupus erythematosus

24 May 2018

Abstract excerpt

Allogeneic mesenchymal stem cell (MSC) transplantation has recently become a promising therapy for patients with systemic lupus erythematosus (SLE). MSCs are a kind of multipotent stem cell than can efficiently modulate both innate and adaptive immune responses, yet those from SLE patients themselves fail to maintain the balance of immune cells, which is partly due to the abnormal genetic background. Clarifying...

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PMID: 29793537
DOI: 10.1186/s13287-018-0898-x

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