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Article

Targeting the gut microbiome to treat the osteoarthritis of obesity

18 Apr 2018

Abstract excerpt

Obesity is a risk factor for osteoarthritis (OA), the greatest cause of disability in the US. The impact of obesity on OA is driven by systemic inflammation, and increased systemic inflammation is now understood to be caused by gut microbiome dysbiosis. Oligofructose, a nondigestible prebiotic fiber, can restore a lean gut microbial community profile in the context of obesity, suggesting a potentially novel...

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PMID: 29669931
DOI: 10.1172/jci.insight.95997

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