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A Gene Constellation in Avian Influenza A (H7N9) Viruses May Have Facilitated the Fifth Wave Outbreak in China.

Cell reports - 17 Apr 2018

Zhu Wenfei, Dong Jie, Zhang Ye, Yang Lei, Li Xiyan, Chen Tao, Zhao Xiang, Wei Hejiang, Bo Hong, Zeng Xiaoxu, Huang Weijuan, Li Zi, Tang Jing, Zhou Jianfang, Gao Rongbao, Xin Li, Yang Jing, Zou Shumei, Chen Wenbing, Liu Jia, Shu Yuelong, Wang Dayan

Abstract excerpt

The 2016-2017 epidemic of influenza A (H7N9) virus in China prompted concern that a genetic change may underlie increased virulence. Based on an evolutionary analysis of H7N9 viruses from all five outbreak waves, we find that additional subclades of the H7 and N9 genes have emerged. Our analysis indicates that H7N9 viruses inherited NP genes from co-circulating H7N9 instead of H9N2 viruses. Genotypic diversity...

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Antigens
Disease Outbreaks
Influenza A Virus, H7N9 Subtype
Influenza, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nucleocapsid Proteins

RNA-Binding Proteins

RNA-Dependent RNA Polymerase

Viral Core Proteins

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PMID: 29669294
DOI: 10.1016/j.celrep.2018.03.081

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