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Article

Generation of Duchenne muscular dystrophy patient-specific induced pluripotent stem cell line lacking exons 45-50 of the dystrophin gene (IITi001-A).

Stem cell research - 1 May 2018

Eisen Binyamin, Ben Jehuda Ronen, Cuttitta Ashley J, Mekies Lucy N, Reiter Irina, Ramchandren Sindhu, Arad Michael, Michele Daniel E, Binah Ofer

Abstract excerpt

Duchenne muscular dystrophy (DMD) is an X-linked progressive muscle degenerative disease caused by mutations in the dystrophin gene. We generated induced pluripotent stem cells (iPSCs) from a 13-year-old male patient carrying a deletion mutation of exons 45-50; iPSCs were subsequently differentiated into cardiomyocytes. iPSCs exhibit expression of the pluripotent markers (SOX2, NANOG, OCT4), differentiation...

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Identifiers

PMID: 29653394
DOI: 10.1016/j.scr.2018.03.023
PMCID: PMC5999581

Genes

DMD
NANOG
SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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