Article
Large-Scale Complete-Genome Sequencing and Phylodynamic Analysis of Eastern Equine Encephalitis Virus Reveals Source-Sink Transmission Dynamics in the United States.
Journal of virology - 15 Jun 2018
Tan Yi, Lam Tommy Tsan-Yuk, Heberlein-Larson Lea A, Smole Sandra C, Auguste Albert J, Hennigan Scott, Halpin Rebecca A, Fedorova Nadia, Puri Vinita, Stockwell Timothy B, Shilts Meghan H, Andreadis Theodore, Armstrong Philip M, Tesh Robert B, Weaver Scott C, Unnasch Thomas R, Ciota Alexander T, Kramer Laura D, Das Suman R
Abstract excerpt
Eastern equine encephalitis virus (EEEV) has a high case-fatality rate in horses and humans, and Florida has been hypothesized to be the source of EEEV epidemics for the northeastern United States. To test this hypothesis, we sequenced complete genomes of 433 EEEV strains collected within the United States from 1934 to 2014. Phylogenetic analysis suggested EEEV evolves relatively slowly and that transmission is...
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