Article
High-level heteroplasmy for the m.7445A>G mitochondrial DNA mutation can cause progressive sensorineural hearing loss in infancy.
International journal of pediatric otorhinolaryngology - 1 May 2018
Matsushima Kana, Nakano Atsuko, Arimoto Yukiko, Mutai Hideki, Yamazawa Kazuki, Murayama Kei, Matsunaga Tatsuo
Abstract excerpt
OBJECTIVE: Hearing loss caused by mutation of mitochondrial DNA typically develops in late childhood or early adulthood, but rarely in infancy. We report the investigation of a patient to determine the cause of his early onset hearing loss. MATERIALS AND METHODS: The proband was a boy aged 1 year and 2 months at presentation. Newborn hearing screening test by automated auditory brainstem response generated "pass"...
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